Is barbituric acid a strong acid?
Score: 4.2/5 (13 votes) Structures of typical barbiturates. In contrast to barbituric acid, which is five times more acidic (pKa 4.0) than acetic acid (pKa 4.75), the 5,5-disubstituted derivatives are only weak acids (pKa about 8). This is of importance for their biological effects and for their ana...